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Vigabatrin(VIG)decreases the breakdown of the inhibitory neurotransmitter y-aminobutyric acid,whereas lamotrigine(LTG)reduces presynaptic excitatory amino acid release.22 patients with refractory epilepsy,treated with an anticonvulsant regimen containing VIG,entered a balanced,double blind, placebo controlled,crossover trial of additional LTG.This study suggests a substantial efficacy for a regimen containing VIG and LTG.Combinations of drugs with complementary modes of action may provide a rational pharmacological approach to the management of refractory epilepsy. |
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lamotrigine
seizure
seizure,intractable
seizure,intractable,treatment of
seizure,treatment of
treatment of neurologic disorder
vigabatrin
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